The study aimed to determine the growth performance and plant adaptation of R. glutinosa (DH19) to the selected plantation locations in Vietnam's Northern Midland and Mountainous regions. The experiments were arranged in a completely randomized block design and performed on three sites in Vinh Phuc, Phu Tho, and Tuyen Quang provinces. Research showed that DH19 was grown and developed well, gaining an average yield of 23.9 to 24.8 tons/ha and the catalpol content from 0.72 - 0.74%. DH19 was adapted to moderate drought conditions but severely damaged and recovered poorly in flooding. Planting DH19 should pay attention to root sores disease (Rhizoctonia solani) at the seedling stage and root rot disease (Fusarium sp.) at the harvest stage. The above study results show that DH19 can be selected for planting in Vietnam's Northern Midland and Mountainous regions.