The article focuses on studying the UK's new strategy, “Global Britain”, after the UK left the European Union (EU). The study has shown the adjustments in the UK's global policy towards regions such as Europe, Latin America, Africa, and the Middle East and defined the critical role of the Indo-Pacific area. Thereby, the author has an assessment of the impact of this strategic adjustment on Vietnam as a basis for policy-making to enhance the effectiveness of cooperation in the relationship between Vietnam and the United Kingdom in the near future.