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Characteristics and properties of chitosan/alginate/lovastatin composite films

Authors:
Thạch Thị Lộc, Thái Hoàng, Lê Đức Giang, Nguyễn Thị Quỳnh Giang, Lê Thị Thủy
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This study aims to learn about the preparation and properties of alginate/chitosan polyme films blend carrying lovastatin drug. Some characteristics of composite films have been investigated by many methods, such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimeter and swelling capacity. The results show that the composite had a relatively homogeneous distribution of lovastatin. The chararcteristic signs in the FTIR of each agent still appeared in the FTIR spectra of the composite films however they had a slightly shift. This proved that the alginate, chitosan and lovastatin had strong interaction together by the dipole-dipole interaction and hydrogen bonding between the amine and hydroxyl groups in chitosan with the carboxyl group in alginate. The melting temperature of the composite films were lower than these of lovastatin and the films were able to swell in water for 3-4 hours, then disintegrate over time as...
This study aims to learn about the preparation and properties of alginate/chitosan polyme films blend carrying lovastatin drug. Some characteristics of composite films have been investigated by many methods, such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimeter and swelling capacity. The results show that the composite had a relatively homogeneous distribution of lovastatin. The chararcteristic signs in the FTIR of each agent still appeared in the FTIR spectra of the composite films however they had a slightly shift. This proved that the alginate, chitosan and lovastatin had strong interaction together by the dipole-dipole interaction and hydrogen bonding between the amine and hydroxyl groups in chitosan with the carboxyl group in alginate. The melting temperature of the composite films were lower than these of lovastatin and the films were able to swell in water for 3-4 hours, then disintegrate over time as alginate dissolved.
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Vinh University journal of science

Tạp chí khoa học Trường Đại học Vinh

ISSN: 1859 - 2228

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