The purpose of the present work is to study the effect of inlet drying temperature (140-170oC), feed flow rate (20-30ml/min) and maltodextrin ratio (10-20%) on the total phenolic content (TPC) and total flavonoid content (TFC) of spray-dryed Nelumbo nucifera extracts using response surface method/technique (RSM). The optimal conditions for spray drying process from leaves of N. nucifera extracts were found to be inlet drying temperature of 141oC, feed flow rate of 30ml/min and maltodextrin ratio of 10%w/v. The experimental values of TPC and TFC were 36.89±0.05mg GAE/g and 9.22±0.02 mgCE/g.