Cyclooligomer depsipeptides (CODs) has been applied in many different fields of science and technology. However, studies on CODs and application of CODs from entomopathogenic fungi in Vietnam are still new. In this paper, the Cordyceps sp. CPA14V strain was isolated from insect samples that were collected from Copia Nature Reserve - Son La. The strain Cordyceps sp. CPA14V produced and intracellularly accumulated CODs with relatively high concentration. The strain grew best on Sabouraud medium. CODs production was highest in Czapek-Dox midum, at the 6th day of incubation, reached 6.45 mg/g. Due to its ability to biosynthesize CODs, the strain Cordyceps sp. CPA14V has great potential of application. Further studies are needed to identify the strain Cordyceps sp. CPA14V to species and to optimize conditions for CODs production.