The renovation of current teaching methods aims to achieve two important goals: Firstly, equip students with the ability to synthesize knowledge, skills, etc. in many different fields to solve problems. Secondly, from the requirement of educational socialization, it is necessary to fulfill the teaching purposes for all students, that is, to ensure that each individual student is trained to improve knowledge and develop capacity. STEM education is one of the solutions to meet the above goals. STEM education demonstrates integration and differentiation in teaching content and organization to equip learners with necessary knowledge and skills, thereby developing problem-solving abilities for all learners. This article deeply explores the integration and differentiation in the topic of STEM education with the development of problem - solving capacity for students through the topic: Chemical fertilizers in high school grade 11 chemistry program.