Quality culture is an indispensable element in building and developing a quality management and assurance system within universities during the integration period. Quality culture building is a major concern of higher education in the Lao PDR because this is one of the decisive factors for the sustainable development of each school as well as the education system of the Lao PDR. The paper presents the issues of quality culture and quality culture building, analyzing some difficulties and advantages in building a quality culture in universities of Lao PDR, thereby proposing recommendations to build quality culture at the unit.