The study was conducted on Pompano (Trachinotus sp.) cultured in the circulation water pond from June 2022 to September 2023. The results show that Pompano were negative for the viral pathogens (VNN and Iridovirus). Fish were infected with Vibrio alginolyticus bacteria in both farming crops. The infection rate is 20% and does not cause fish deaths in the June 2022 and April 2023 sampling periods. Meanwhile, in the July 2022 sample collection, the 60% infection rate caused the death of 4.2% of farmed fish. Doxycycline antibiotic used by mixing with food at a dose of 100 mg/kg of fish, feeding fish 1 meal/day for 5 consecutive days was effective in treatment, no fish died after the 6th day; Farmed fish weighing 30-55 g/fish are infected with the parasite Amyloodinium sp. at high infection intensity (100-190 parasites/market) caused 29.1% mortality; These fish were bathed with formol at a dose of 50 ppm. After 3 consecutive baths, 1 day apart each time, the fish stopped dying for 10 days. Parasites Trichodina sp. appear on Pompano with a weight of 80-120 g/fish, infection intensity is 0-5 infections per field (in gills) and 0-15 infections per field (in skin) but does not cause fish death. In larger fish, high intensity Trichodina sp. parasite infection has caused mortality. Specifically: Fish weighing 90-120 g/fish have an infection intensity of 100-250 infections per field, with an infection rate of 100%, causing 12.7% mortality; Fish with weight of 260-320 g/fish, intensity of 10-50 infections per field, infection rate 100%, causing 2.7% mortality. Using copper sulfate at a dose of 5 ppm completely eliminated Trichodina sp. after 3 consecutive baths, 1 day apart.