The paper presents an experimental research results of reinforced concrete slab with opening hole strengthened by CFRP (Carbon Fiber Reinforced Polymer). The study were carried out on 5 reinforced concrete slabs with the same geometric size and material composition, including 1 non-reinforced slab (reference slab), 04 slabs reinforced by CFRP in two various ways. The results obtained through this study will contribute to clarifying the behavior of reinforced concrete floors with opening holes reinforced by CFRP materials. In addition, the evaluation results show the reinforcement effect from the selection of CFRP sheet reinforcement, the bearing capacity of the reinforced floor increased by over 70%.