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Molecular characteristic analsis of non-small cell lung cancer patients at Nghe An Oncology Hospital

Authors:
Nguyễn Quang Trung, Nguyễn Thị Thuỷ Lê, Trần Đức Hùng, Ngô Thị Tố Trinh, Võ Thị Quỳnh Trang, Nguyễn Thị Giang An
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By conducting the study on 109 non-small cell lung cancer (NSCLC) patients at the Nghe An Oncology Hospital, we found that EGFR gene mutation is a cause of NSCLC. The average age of patients is 63.8 ± 10.6. 96.33% of all the patients have Adenocarcinoma. Using Scorpion ARMS technique for EGFR mutation identification, we found the rate of patients carrying the gene mutation was 40.37%. 55.96% of the patients are male (27.87% of those have gene mutation), 44.04% are female (56.25% of those have gene mutation). In all patients with gene mutations, 54.55% of patients carry LREA and L747-P753 delinsS mutation at exon 19. The rate of patients with the L858R gene mutation at exon 21 is 29.55%; the rate of double mutation at exon 19 and 20, 18 and 20, 18 and 21 is 9.09%. 15.91% of patients have targeted-drug-resistant gene mutation.
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Vinh University journal of science

Tạp chí khoa học Trường Đại học Vinh

ISSN: 1859 - 2228

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License: 163/GP-BTTTT issued by the Minister of Information and Communications on May 10, 2023

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